Partial Inhibition of Integrin avb6 Prevents Pulmonary Fibrosis without Exacerbating Inflammation
نویسندگان
چکیده
Departments of Exploratory Biology, Fibrosis, Protein Chemistry, Gene Discovery, Molecular Profiling, and Clinical Sciences and Technology, Biogen Idec, Cambridge, Massachusetts; Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania; Division of Rheumatology, Mayo Clinic, Rochester, Minnesota; Section of Rheumatology, Department of Pathology, Boston University School of Medicine, Boston, Massachusetts; Pulmonary Disease and Critical Care Medicine Unit, Department of Medicine, University of Vermont, Burlington, Vermont; and Lung Biology Center, University of California San Francisco, San Francisco, California
منابع مشابه
The role of integrins in pulmonary fibrosis
Integrins are a large family of transmembrane glycoprotein receptors initially identified as mediators of cell adhesion and tissue integrity. However, it is now known that the primary function of integrins in mammals is to act as signalling proteins. Signals from integrins are known to play critical roles in virtually every aspect of the behaviour of epithelial cells and in the development of c...
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متن کاملIn vivo IL-10 gene delivery attenuates bleomycin induced pulmonary fibrosis by inhibiting the production and activation of TGF-b in the lung
Backgroud: Idiopathic pulmonary fibrosis is a devastating disorder for which there is no effective treatment. Transforming growth factor (TGF)-b plays a critical role in provoking fibrosis. Interleukin (IL)-10 is a potent immunosuppressive cytokine but its effect on the fibrosing process is unclear. A study was undertaken to examine whether IL-10 affects the production and activation of TGF-b a...
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Backgroud: Idiopathic pulmonary fibrosis is a devastating disorder for which there is no effective treatment. Transforming growth factor (TGF)-b plays a critical role in provoking fibrosis. Interleukin (IL)-10 is a potent immunosuppressive cytokine but its effect on the fibrosing process is unclear. A study was undertaken to examine whether IL-10 affects the production and activation of TGF-b a...
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تاریخ انتشار 2007